Wed, 09 Jan 2019 to Thu, 10 Jan 2019
2019 Course Information
The Course in Applied Molecular Pathology addresses the application of molecular concepts and techniques in the practice of contemporary diagnostic cancer pathology. The course uses hereditary colon cancer, lung cancer and diffuse large B-cell lymphoma as exemplars. Each of these tumour types is the focus of a half-day session led by a pathology subspecialist and a molecular diagnostics clinical scientist with supporting on-line material on basic genetic concepts and genetic laboratory techniques. The course is case-based, highly interactive and builds on fundamental molecular / genomics concepts to highlight the clinicopathological indications, application, interpretation and trouble-shooting of commonly used molecular assays.
After attending this course, participants will be able to:
- Diagnose hereditary cancer based on the appropriate application of diagnostic and screening tests;
- Become familiar with the important preclinical issues that can impact the use of tissue samples for commonly used molecular tests, including DNA sequencing, PCR-based tests, RNA-based tests and fluorescence in situ hybridization;
- Ascertain the likely significance of DNA sequence variants using multiple criteria, including variant type and information from publicly accessible online databases;
- Interpret the results of molecular tests in light of their potential role in perturbing signal transduction pathways that are implicated in cancer;
- Invoke molecular tests appropriately based upon clinical and/or pathological indications;
- Incorporate findings from morphological, immunophenotypic and molecular tests into a unified, clinically actionable report.
This course will be of interest to pathology residents and Canadian College of Medical Genetics trainees as well as practicing pathologists, laboratory geneticists, pathologists’ assistants and others.
This event is an Accredited Group Learning Activity (Section 1) as defined by the Maintenance of Certification (MOC) program of The Royal College of Physicians and Surgeons of Canada (RCPSC), and approved by the Canadian Association of Pathologists – Association canadienne des pathologistes (CAP-ACP).
Through an agreement between the Royal College and Surgeons of Canada and the American Medical Association (AMA), physicians may convert Royal College MOC credits to AMA PRA Category 1 CreditsTM. Information on this process can be found at www.ama-assn.org/go/internationalcme.
Disclosure of Potential Financial Conflicts of Interest
In keeping with accreditation guidelines, speakers participating in this event have been asked to disclose to the audience any financial involvement with industry or other organizations that may potentially influence the presentation of the educational material. Disclosure may be done verbally or using a slide prior to the speaker’s presentation.
This course was initiated and developed as a collaboration between the Ontario Molecular Pathology Network, the Canadian Association of Pathologists and the Anatomical Pathology Specialty Committee of the Royal College of Physicians and Surgeons of Canada.